Companies

Accipiter Biosciences

accipiterbio.com

Accipiter Biosciences designs multifunctional de novo protein therapeutics for complex diseases using computational protein design.

HQSeattle, Washington, United States
Employees11-50
Funding$12.7M
Revenue$1M-5M
Profile 1mo ago
Healthcare AIAI ApplicationAPI / PlatformSeries A$10M-$50M

About

Accipiter Biosciences develops de novo, computationally designed protein therapeutics for complex diseases, including cancer and autoimmune disorders. Its commercial counterparts include pharmaceutical companies such as Pfizer and Kite Pharma; its key differentiator is combining multiple therapeutic mechanisms in one stable protein rather than relying on traditional drug combinations.

Market

Accipiter competes in computationally enabled biologics and de novo protein therapeutics, with an initial focus on autoimmunity and oncology and a partnering model aimed at pharmaceutical and cell-therapy companies. Its differentiation is the design of single-agent, multifunctional proteins that can activate multiple pathways or receptors simultaneously, rather than relying on conventional drug combinations or primarily blocking multispecific antibodies, with reported design-to-lab cycles of under two months.

Target Customers

Accipiter primarily targets mid-size to large pharmaceutical and biotechnology companies developing complex therapies in immunology, oncology, and cell therapy. Likely buyers are biologics-discovery, oncology/immunology R&D, cell-therapy, and business-development leaders seeking partnered discovery, licensing, or custom multifunctional protein programs.

At a Glance

Problem

Accipiter Biosciences is focused on the difficulty of treating complex diseases when a single biological mechanism is not enough. Traditional combination therapies can address multiple pathways, but they bring limitations associated with coordinating several treatments; the company’s stated goal is to create one therapeutic capable of mounting a multi-pronged attack. The available research does not quantify the economic cost of these limitations, but the central value proposition is to simplify and improve the treatment of diseases that require simultaneous biological activity.

The clearest use cases appear to be oncology and other complex diseases involving multiple cell-signaling pathways. Accipiter specifically describes candidates designed to activate more than one cell-surface receptor on the same cell at the same time, while its partnerships include Pfizer for new therapeutic molecules and Kite for proteins used in cell therapies.

Product / Service

Accipiter develops computationally designed, de novo protein therapeutics rather than relying only on proteins found in nature. Its platform creates fully customizable, multifunctional proteins that combine multiple therapeutic mechanisms in one stable molecule. These proteins are purpose-built to engage multiple receptors simultaneously, with the intended benefit of achieving combination-like biological activity through a single agent and avoiding the limitations of conventional combination approaches.

The company appears to operate both as a drug-development platform and through strategic collaborations. It has a collaboration and license agreement with Pfizer to research and engineer new molecules, and an agreement with Kite to design proteins for cell-therapy applications. The platform is therefore monetized through partnered research, upfront funding, potential milestones, royalties, and possible licensing or acquisition of resulting molecules, rather than through a disclosed marketed product.

Market

Accipiter competes in computational protein design and engineered biologics, with a focus on multifunctional or multi-mechanism proteins for complex diseases. Its closest alternatives include conventional biologics and combination therapies, while its oncology and cell-therapy programs place it near companies developing immune, receptor-targeting, and cell-engineering therapeutics. No specific direct competitor is named in the available research, so the company’s competitive position is best understood as an emerging platform category rather than a clearly defined head-to-head market.

The company has meaningful early commercial traction but appears to be development-stage rather than a mature commercial therapeutics business. It emerged from stealth with $12.7 million and partnerships with Pfizer and Kite. The Pfizer collaboration includes upfront funding, potential milestone payments and royalties, with more than $330 million possible if specified milestones are reached; the Kite arrangement likewise includes initial funding, potential milestones and royalties, plus an option to acquire molecules for global development and sales. No approved product or product revenue is disclosed in the available material.

Founders & Leadership

Matthew BickFounder
CEO and Co-founder
Javier CastellanosFounder
Chief Technologist and Co-founder
Hector Rincon-AranoFounder
Chief Scientist and Co-founder
William CanestaroChief Operating Officer and Chief Strategy Officer

Funding History

2023-04
Seed$840K

Not publicly disclosed

2025-11
Seed$12.7M

Takeda, Flying Fish Partners

Recent News

2026-07-31funding
Moving faster than planned, AI drug developer Accipiter Bio quietly tops up seed round with $10.5M

Accipiter Biosciences raised an additional $10.5 million from existing investors to accelerate development of AI-designed, multi-target protein therapeutics. The company plans to expand its team and increase its clinical-stage drug candidates, with growing emphasis on immunology.

2025-11-06funding
Accipiter Biosciences Emerges from Stealth with $12.7 Million in Seed Financing to Deliver de novo Protein Therapies for Complex Diseases

Accipiter Bio publicly launched with $12.7 million in seed financing co-led by Takeda and Flying Fish Partners. Funding will support its immunology and oncology pipeline, computational platform, and advancement of up to two programs toward pre-IND studies.

2025-11-06partnership
Accipiter Bio enters research collaboration and license agreement with Pfizer

Accipiter Bio and Pfizer entered a research collaboration and license agreement to discover and design biologics for multiple targets. Accipiter received an upfront payment and is eligible for more than $330 million in potential milestones plus royalties.

2025-11-06partnership
Accipiter Bio enters multitarget agreement with Kite Pharma

Accipiter Bio announced a multitarget agreement with Kite Pharma, a Gilead company, to generate molecules for use in cell therapies. Kite received an option to acquire selected molecules for worldwide therapeutic development, with Accipiter eligible for upfront, milestone, and royalty payments.

2025-11-06
Seattle startup Accipiter Bio emerges with $12.7M and big pharma deals for AI-designed proteins

GeekWire covered Accipiter Bio’s emergence from stealth, reporting the $12.7 million seed round and partnerships with Pfizer and Kite Pharma. The article describes the company’s use of AI to design multifunctional proteins and outlines the commercial terms of its collaborations.

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Business Model

The available evidence does not disclose a specific pricing model or product revenue. Accipiter appears to monetize through pharmaceutical partnerships and collaborations, alongside internally developed therapeutic programs that may generate future licensing or commercialization revenue.

Products

Post-evolutionary de novo protein therapeuticsCustom-engineered multifunctional single-agent biologics that combine multiple mechanisms in one stable proteinAutoimmunity programs focused on targeted agonist delivery and regulatory T-cell modulationOncology programs designed for tunable activity and reduced systemic toxicityPartnered biologics and protein molecules for pharmaceutical targets and cell therapies

Customers

Pfizer (research collaboration and license agreement)Kite Pharma, a Gilead Company (multitarget agreement)

Tech Stack

Computational protein designNovel proprietary computational methods and computer modelsMachine learningHigh-performance computing infrastructureHigh-throughput experimentationIn silico protein design with in vitro and in vivo validation

Competitors

Generate:Biomedicines
Absci
Profluent
Neoleukin Therapeutics

Key Investors

Flying Fish Partners, Takeda Ventures, Alexandria Venture Investments, Argonautic Ventures, Cercano Management, Columbus Venture Partners, Pack Ventures, WRF Capital