Companies

Lumius

lumius-imaging.com

Lumius develops affordable, portable, intelligent 3D ultrasound systems for clinical imaging and vascular access.

HQDurham, North Carolina, United States
Employees1-50
1 active role
Jobs checked 3h ago
Healthcare AIAI-EnhancedHardware

About

Lumius is developing compact, portable, real-time 3D ultrasound systems for clinicians and hospitals, initially targeting vascular-access procedures and later other diagnostic and guidance use cases. Its differentiator is Diffractive Acoustic Tomography, which the company says delivers high-resolution 3D imaging while costing 50 times less than traditional matrix-array 3D probes.

Market

Lumius competes in medical-imaging devices, specifically portable point-of-care ultrasound and the 3D ultrasound market. It positions a compact, affordable, real-time 3D system around vascular-access guidance, aiming to eliminate the mental reconstruction and procedural guesswork associated with 2D ultrasound. Its stated differentiation is DAT-based large-volume imaging combined with AI assistance at substantially lower cost and greater portability than incumbent 3D systems, while offering capabilities beyond lower-cost 2D POCUS products such as Butterfly Network.

Target Customers

Lumius primarily targets hospitals, clinical proceduralists, and hospital innovation teams working with vascular access, central-line placement, nerve blocks, and other ultrasound-guided procedures. Secondary customers include medical-device innovators and healthcare/medtech organizations interested in 3D imaging guidance.

At a Glance

Problem

Lumius addresses the usability and cost limitations of conventional ultrasound. Most ultrasound remains 2D, forcing clinicians to move the probe while mentally reconstructing three-dimensional anatomy from thin slices. That makes procedures difficult to learn and perform consistently, particularly for less-experienced clinicians. The economic pain is substantial: existing 3D ultrasound systems cost roughly ten times more than standard 2D machines, while hospitals spend millions of dollars each year training clinicians on 2D ultrasound.

The initial and clearest use case is vascular access, especially central-line placement. Lumius says roughly 50% of first attempts fail, particularly among new clinicians, making vascular access a high-frequency procedure where better visualization could reduce failed attempts and training burden. Longer term, the company identifies blood-clot detection, nerve blocks, tumor diagnosis, and biopsy guidance as potential extensions.

Product / Service

Lumius is developing a compact, portable, hardware-based 3D ultrasound system with real-time imaging and AI assistance. Its stated goal is to provide an on-the-fly view of a volume rather than a thin 2D slice, helping users see anatomy in context and reducing the probe-coordination and interpretation burden. The system is described as affordable, with the company claiming its technology can cost 50 times less than a traditional matrix-array 3D probe, while offering a 4-by-4-by-4-centimeter field of view with near-isotropic resolution.

The underlying approach is Diffractive Acoustic Tomography, or DAT. The research behind the technology adapts an off-the-shelf linear ultrasound transducer and uses fast focal-line reconstruction to produce 3D ultrasound, with the broader research platform also supporting photoacoustic imaging. Lumius plans to add context-aware AI that can identify structures such as blood vessels, nerves, and muscle and guide the user on what is being seen and what to do next. The public materials still carry an important limitation: the products have not been evaluated by the FDA and are not intended for diagnosis or treatment.

Market

Lumius competes in medical imaging, specifically portable point-of-care ultrasound and the emerging affordable 3D ultrasound category. Its alternatives include conventional 2D ultrasound, expensive 3D systems used primarily for cardiac and fetal imaging, and adjacent handheld POCUS products from companies such as Clarius and Butterfly; GE Vscan is also cited in the handheld-ultrasound comparison landscape. These handheld vendors are relevant usability and portability comparables, although Lumius is differentiated by pursuing real-time volumetric imaging rather than only conventional handheld 2D scanning.

The company appears to be at an early commercialization stage rather than an established commercial vendor. It is listed by Y Combinator as an active Spring 2026 company, with an open hardware-and-embedded engineering role, and PitchBook reports $500,000 of funding with Y Combinator identified as an investor. The available evidence does not disclose paying customers, deployed systems, or revenue, so current traction is best characterized as launch, technical development, and initial clinical-use-case validation rather than demonstrated commercial scale.

Founders & Leadership

Tri VuFounder
Co-Founder & CEO
Luca MenozziFounder
Co-Founder & CTO
Chenhang LiFounder
Co-Founder & CFO/COO
Junjie YaoFounder
Scientific Advisor & Co-founder

Funding History

2026-04
Accelerator/Incubator (YC pre-seed)$500K

Y Combinator, 007 Venture Partners, FundersClub, Boost VC, Robinhood Ventures, Vento Ventures

2026-06
Non-dilutive ARPA-H subcontract$370K

ARPA-H

Recent News

2026-07-15
Lumius listed among Y Combinator's 2026 healthcare startups

Lumius appears in Y Combinator's 2026 healthcare-startup directory as an active company building accessible 3D ultrasound systems.

2026-06-26funding
Lumius: Fast, smart, accessible 3D ultrasound that anyone can use

007 Venture Partners announced its investment in Lumius alongside FundersClub, Boost VC, Robinhood Ventures, Vento Ventures, and Y Combinator. The article reports $370,000 in non-dilutive ARPA-H subcontract funding and $5.7 million in signed letters of intent, while outlining Lumius's real-time 3D ultrasound and AI-assisted mixed-reality platform.

2026-06-25
Lumius - The YC Tier List

A YC-focused profile describes Lumius as building fast, smart, accessible 3D ultrasound systems intended to eliminate the guesswork associated with conventional 2D ultrasound.

2026-05-08product
Launch YC: Lumius — The 3D Camera for the Body

Lumius launched on Y Combinator's Launch YC platform with a product vision centered on real-time, affordable, portable 3D ultrasound. Its initial focus is vascular access and central-line placement, with planned applications including biopsy guidance, tumor diagnosis, and nerve-block imaging.

2026-04-09
Lumius Imaging Funding | Complete Analysis

Extruct AI published an analysis of Lumius Imaging's product and market positioning, describing the company as developing a fast, smart, accessible 3D ultrasound device and presenting it as a 3D camera for the body.

2026-02-09product
Lumius: Accessible 3D ultrasound — Technology

Lumius's technology page presents Diffractive Acoustic Tomography as the core of its compact, portable 3D-imaging platform, designed to provide high-resolution imaging while addressing the cost and quality tradeoff in ultrasound.

Active Roles

1
Durham, NC, US / Remote (San Francisco, CA, US; Seattle, WA, US)/Engineering/33d ago

Business Model

Lumius appears to be pursuing a business-to-business medical-device model, selling affordable 3D ultrasound systems to hospitals and clinical users, initially for vascular access. Public sources do not disclose finalized pricing, revenue, or whether software and service subscriptions will complement device sales.

Products

Portable real-time 3D/4D ultrasound system with DAT, isotropic resolution, and a wide 4×4×4 cm field of viewVascular-access and central-line guidance workflow, which is Lumius’s initial clinical focusPlanned AI-assisted imaging applications including blood-clot detection, nerve-block imaging, tumor diagnosis, and biopsy guidance

Customers

Y CombinatorDuke UniversityHumanXColumbiaAndromedaNCBC

Tech Stack

Real-time 3D/4D ultrasound imagingDiffractive Acoustic Tomography (DAT) and 3D image reconstructionCompact, portable ultrasound hardware with isotropic resolution and wide field of viewAI-assisted, context-aware anatomical detection and procedural guidance

Competitors

Philips
GE HealthCare
Supersonic Imagine
Butterfly Network