Companies

Signatur Biosciences

signatur.bio

Signatur Biosciences converts standard qPCR equipment into decentralized precision-diagnostic tools for complex diseases.

HQLondon, Not applicable, United Kingdom
Employees1-50
Jobs checked 4d ago
Specialization
Biotechnology
Business
Scientific Research
Market
Healthcareand 1 more market values
  • Life Sciences
Ecosystem
Not applicable
Customers
Enterprisesand 1 more customers values
  • Researchers
More details
Organization type
Commercial Company
Ecosystem
Not applicable
Business
Scientific Research
Specialization
Biotechnology
Market
Healthcare, Life Sciences
Customers
Enterprises, Researchers
Delivery models
Not classified
Revenue models
Not classified
Listing status
Not classified
Latest equity round
Seed
Reported funding amount
Not classified

About

Signatur Biosciences is a B2B molecular-diagnostics company developing smart PCR kits and the PCRchitectur platform for hospitals, clinical laboratories, and diagnostic partners. Its tests condense complex gene-expression signatures into a single reaction on standard qPCR equipment, making precision diagnostics faster, cheaper, and more decentralized than centralized genomic testing.

Market

Signatur competes in B2B molecular diagnostics and precision oncology, initially targeting breast-cancer prognostic testing that traditionally depends on centralized genomic laboratories. Its differentiation is a decentralized, single-reaction qPCR approach that compresses complex RNA signatures onto standard hospital instruments, aiming to deliver same-day or few-day results at substantially lower material cost while preserving the clinical utility of reference-lab assays.

Target Customers

Ideal customers are hospitals and clinical laboratories—especially decentralized labs with standard qPCR equipment—whose clinicians and laboratory teams need rapid breast-cancer prognostic results. On the partner side, Signatur targets B2B molecular-diagnostics companies developing biomarker panels, genomic tests, or gene-expression assays.

At a Glance

Problem

Precision breast-cancer prognosis is often delivered through centralized genomic assays that can cost around $4,000, require international sample shipment, and take up to three weeks. That combination of expense, logistics, and delay leaves many women without timely information to guide treatment, particularly in regions without advanced reference laboratories. The killer use case is making prognostic testing available locally to hospitals and clinical laboratories using infrastructure they already have.

Product / Service

Signatur’s first product, OncoSignatur Breast, is a decentralized test kit under development for local breast-cancer prognostic testing. Its proprietary PCRchitectur technology condenses complex RNA or gene-expression signatures into a single streamlined qPCR reaction that runs on standard machines and fits existing hospital workflows. The intended benefit is same-day or near-term results, lower material costs—claimed to be up to 20-fold lower than conventional methods—and comparable clinical utility to reference-lab genomic assays, without requiring expensive specialized equipment.

Market

Signatur competes in precision molecular diagnostics, initially targeting the breast-cancer genomic-prognosis market. Its comparison set includes established genomic assays such as Oncotype DX, MammaPrint, EndoPredict, Prosigna Breast Cancer Assay, and Breast Cancer Index, as well as technically adjacent RT-qPCR approaches such as MammaTyper. Signatur’s differentiation is not simply another centralized gene-expression test, but a lower-cost, decentralized delivery model built around ordinary qPCR equipment.

The company appears pre-commercial rather than an established revenue-generating diagnostics provider: its own materials describe OncoSignatur Breast and the underlying technology as under development and not available for sale. It has nevertheless demonstrated meaningful financing traction, closing a $7 million seed round in May 2025 and reporting $9.9 million in total funding, intended to support product development, validation, a dedicated laboratory, team expansion, and commercialization activities. Public evidence reviewed here does not establish launched-product revenue or customer adoption.

Founders & Leadership

Celestin de WergifosseFounder
Co-founder and CEO
John GoertzFounder
Co-founder, Scientific Advisor, and PCRchitect
Prof. Dame Molly StevensFounder
Co-founder and Scientific Advisory Board Chair
Adrian MoodyChief Development Officer
Bertrand DuquesneChief Operating Officer
Vincent ColinChief Financial Officer

Funding History

2022-09
Pre-Seed$500K

Y Combinator

2023-12
Grant (Innovate UK)£689,225

Innovate UK (UKRI)

2025-05
Seed$7M

The Discovery Lab of IBA (Ion Beam Applications), Noshaq

Recent News

2026-02-10other
Signatur Biosciences: New laboratory facility in Liège, Belgium

A Signatur Biosciences company update states that the startup is establishing a new laboratory facility in Liège, Belgium, while maintaining a predominantly London-based remote workforce.

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Business Model

Signatur is pursuing a pre-commercial B2B model built around partnerships with molecular-diagnostics companies and deployment of its PCR kits and platform by hospitals and clinical laboratories. Public pricing and current revenue are not disclosed; the company states that its technology and products remain under development and are not yet for sale.

Products

OncoSignatur Breast (product under development)PCRchitectur platform for decentralized precision-molecular-diagnostic assays

Tech Stack

PCRchitectur molecular technologyStandard qPCR instrumentation and workflowsRNA/gene-expression signature compression into single PCR assaysMachine-learning-informed molecular design

Competitors

Oncotype DX Breast Recurrence Score
MammaPrint
Prosigna Breast Risk of Recurrence
EndoPredict
MammaTyper