Companies

Simplex

simplex.sh

Simplex provides AI agents that autonomously complete healthcare provider enrollment with payors across legacy portals.

HQSan Francisco, California, United States
Employees1-50
Jobs checked 5d ago
Specialization
Not classified
Business
Software Applications
Market
Healthcare
Ecosystem
Agents
Customers
Enterprisesand 1 more customers values
  • Small Businesses
More details
Organization type
Commercial Company
Ecosystem
Agents
Business
Software Applications
Specialization
Not classified
Market
Healthcare
Customers
Enterprises, Small Businesses
Delivery models
Hosted Software
Revenue models
Usage Based
Listing status
Not classified
Latest equity round
Not classified
Reported funding amount
Not classified

About

Simplex builds AI agents that automate provider enrollment with payors end to end, including collecting CAQH data, completing forms, uploading licenses, handling corrections, and following up on effective dates. It targets organizations managing healthcare provider enrollment and differentiates through autonomous execution across payor portals, email, and phone, together with integration into existing software systems.

Market

Simplex competes in healthcare administrative automation, specifically provider credentialing and payer enrollment, with adjacent payer-portal workflows such as prior authorization, patient intake, and claims. It positions itself as an API-connected, production-grade AI-agent layer that executes work across CAQH and commercial-payer portals rather than functioning only as a conventional credentialing system. Its differentiation is end-to-end execution on difficult legacy portals—including browser automation, high-concurrency sessions, CAPTCHA/2FA handling, daily status polling, corrections, appeals, and workflow evaluations—combined with integration into customers’ existing systems.

Target Customers

The ideal customers are healthcare technology companies—especially telehealth nutrition marketplaces, behavioral-health platforms, and other provider-network businesses—that need to enroll clinicians across commercial payers. Simplex is aimed at scaling or enterprise teams, with likely buyers in healthcare operations, provider-network management, credentialing/enrollment, and platform engineering who need the workflow integrated into an existing software stack.

At a Glance

Problem

Simplex addresses the labor-intensive, fragmented work required to enroll healthcare providers with commercial payers. Enrollment spans CAQH profiles, payer-specific forms, licenses, portals, email, phone calls, corrections, and repeated status follow-ups; the underlying payer portals are often unintuitive or broken. The economics are painful because a provider may be unable to bill insurance while enrollment is pending: one industry estimate puts the typical timeline at 60–90 days and more than 20 staff hours per application, with $6,000–$8,000 in lost monthly revenue per provider during delays.

The killer use case is a fast-growing digital-health or telehealth business onboarding clinicians across multiple states and payers. A single physician licensed in all 50 states can create an enrollment record for every state-payer combination, while therapists and dietitians can generate dozens of enrollments, making manual operations a direct constraint on provider capacity, revenue activation, and patient access.

Product / Service

Simplex is an AI-agent and API-based provider-enrollment service that runs the workflow end to end. A customer sends its provider roster; Simplex verifies NPIs, licenses, and demographics, creates or updates CAQH profiles, submits applications through payer portals and other channels, polls for status, handles corrections, and appeals or resubmits denials until the payer issues a final determination and effective date.

The delivery model combines a software API with white-glove integration into the customer's existing provider-data systems. It supports major commercial payers and multiple specialties, provides real-time status updates, and is designed to handle the authentication, CAPTCHA, and portal irregularities that make generic browser automation unreliable. Pricing is a flat fee per finished enrollment, charged when the payer reaches a final disposition rather than per seat, credit, or attempt; the company also represents the service as HIPAA compliant and SOC 2 compliant.

Market

Simplex competes in healthcare automation, specifically provider enrollment, credentialing, and payer-portal workflow automation. Its differentiated angle is execution: rather than only organizing provider data or tracking tasks, its agents actually operate legacy payer systems and manage submissions through effective-date confirmation. Relevant competitors and adjacent platforms include CertifyOS, Medallion, and Verifiable, while internal credentialing teams, outsourced enrollment services, and custom Playwright or browser-agent tooling are alternatives for buyers.

The company appears to be an early commercial startup rather than a demonstrably scaled incumbent. Y Combinator lists it as founded in 2024, part of Summer 2024, active, and originally a two-person team; the profile also says customers were using its broader web-agent platform in production. The current site offers a request-demo sales motion and pay-per-enrollment pricing, but the evidence gathered does not disclose named customers, customer counts, revenue, or a verified enrollment-volume metric. That supports describing Simplex as commercially available with early traction signals, not conclusively as pre-revenue or as a scaled market leader.

Founders & Leadership

Shreya KarpoorFounder
Co-founder and CEO
Marco NocitoFounder
Co-founder and CTO

Funding History

2024-09
Seed (Crunchbase labels it Pre-Seed)$500K

Y Combinator

Recent News

2026-04-07other
Prior Auth Submission: The Complete Guide for Health Tech Companies

Simplex published a guide covering the three main prior-authorization submission channels: phone, fax, and payer portal.

2025-10-02product_launch
Launch HN: Simplex (YC S24) – Browser automation platform for developers

Simplex founders Marco Nocito and Shreya Karpoor publicly introduced infrastructure for browser automation, including remote browsers and steerable web agents. The founders said the platform had spent nearly a year working with real customers and offered both a dashboard and API.

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Business Model

Simplex charges a flat price for each finished enrollment rather than per seat, credit, or attempt. Its published model has no platform fee, seats, or minimums and is month-to-month.

Products

Simplex Provider Enrollment API and AI-agent service for CAQH setup, provider-data verification, payer applications, status tracking, corrections, appeals, and effective-date follow-upSimplex enterprise-grade web-agent platform and infrastructure for automating legacy portalsAdjacent payer-portal automations for prior authorization, patient intake, and claims

Customers

No named enterprise customers publicly disclosed

Tech Stack

LLMsAI agents and multi-agent orchestrationBrowser automation for legacy payer portalsAPI and database integrationsConcurrent browser sessions with CAPTCHA, 2FA, and portal authentication handlingWorkflow evaluation, action caching, and production reliability toolingNPI-registry-based data validation

Competitors

Medallion
CertifyOS
CredentialStream
ClinicMind
QGenda