Companies

Xaira Therapeutics

xaira.com

Xaira uses artificial intelligence, biological data, and drug development expertise to discover and advance transformative medicines.

HQSouth San Francisco, California, United States
Employees201-1000
Funding$1B
Valuation$2.7B
Revenue$20.2M ARR
22 active roles
Profile 1mo agoJobs checked 1h ago
Healthcare AIAI ApplicationAPI / PlatformSeries A$1B+

About

Xaira Therapeutics is an integrated biotechnology company developing AI-enabled methods, biological datasets, and therapeutics to discover and advance new medicines. It ultimately serves patients and healthcare systems while pursuing partnerships with drug-development organizations; its differentiation is integrating AI research, large-scale data generation, and therapeutic development end to end.

Market

Xaira competes in the AI-native drug-discovery and integrated biotechnology market, applying AI across target biology, therapeutic design, preclinical development, and clinical development. Its differentiation is an end-to-end model that combines advanced AI research, proprietary biological-data generation, and internal therapeutic product development, rather than focusing only on a single computational chemistry or software layer. This places it alongside peers such as Recursion, Insilico Medicine, Generate Biomedicines, Isomorphic Laboratories, Exscientia, Vilya, and Valo.

Target Customers

Xaira primarily serves the pharmaceutical and biotechnology drug-development ecosystem, especially R&D leaders and computational biology, translational medicine, and therapeutic-development teams seeking AI-enabled discovery. It appears to operate mainly as an AI-native therapeutics developer that uses its platforms internally to build drug pipelines, rather than as a conventional standalone software vendor.

At a Glance

Problem

Drug discovery is a slow, expensive, and failure-prone process: bringing a new medicine to market can take more than 10–15 years and cost roughly $1–2 billion on average, with some estimates placing the fully loaded cost at $2.6 billion. The core scientific problem is threefold: identifying the disease’s causative biology, designing a molecule that can correct it, and determining which patients are most likely to benefit. Xaira’s economic thesis is that an engineered, AI-driven process can improve the probability of success while reducing development time and cost.

The main use case is discovering medicines for diseases and biological targets that conventional approaches have struggled to address. Xaira is particularly focused on previously difficult-to-drug targets and on large-molecule therapeutics, using better biological understanding and patient selection to turn otherwise inaccessible mechanisms into viable treatments.

Product / Service

Xaira is an integrated biotechnology company rather than a conventional software vendor. It combines advanced machine-learning research, large-scale biological and clinical data generation, and in-house therapeutic development. Its models are intended to operate across the full workflow, from identifying disease-relevant biology and designing drug-like molecules to selecting patients and informing clinical development. The company’s data platform spans molecular-to-human biology and uses functional genomics and proteomics to investigate causal relationships behind disease.

The platform includes AI methods for de novo protein and antibody design, including work derived from RFdiffusion and RFantibody, alongside models for biological discovery and clinical translation. Xaira’s experiments are designed to generate additional data that improves its models, creating a feedback loop between computation, laboratory work, and development. In 2026, it also launched X-Cell, a virtual-cell model trained on the X-Atlas/Pisces genome-wide perturbation dataset, which contains 25.6 million perturbed single-cell transcriptomes. The intended benefit is a repeatable discovery engine that produces a pipeline of differentiated medicines, including therapies against targets that have resisted traditional approaches.

Market

Xaira competes in the emerging AI-native drug-discovery and next-generation biopharmaceutical market. Its closest public peers include Recursion, which applies AI to cellular imaging and drug discovery; Insilico Medicine, which describes an end-to-end AI drug-discovery pipeline; and Isomorphic Labs, which develops predictive and generative AI for designing molecules and modeling biology. Unlike a pure platform company, Xaira’s stated model is to use its technology internally to discover and develop its own medicines across multiple modalities.

The company launched with more than $1 billion in committed capital, an unusually large financing base for an early biotech, and has since demonstrated platform traction through its biological datasets, virtual-cell work, and an active pipeline of de novo biologics across multiple indications. However, its public disclosures remain light on named disease programs and candidates, and 2026 reporting described partnership activity as focused on building preclinical models and validating the pipeline. The evidence does not establish product revenue or an approved commercial medicine, so Xaira is best characterized as a well-funded, pre-commercial or pre-revenue biotech whose value remains tied to converting its AI and data platform into clinical and ultimately commercial assets.

Founders & Leadership

Marc Tessier-LavigneFounder
Chairman & Chief Executive Officer
David BakerFounder
Scientific Advisor
Arvind RajpalFounder
Executive Chairman / Investor
Hetu KamisettyFounder
Chief Technology Officer
Joe Watchwell WatsonFounder
Co-Founder
Don KirkpatrickFounder
Co-Founder (current operating title not identified)
Ci ChuChief Discovery Officer
Paulo FontouraChief Medical Officer
Debbie LawChief Scientific Officer
Julia TranChief People Officer
Bo WangChief AI Scientist
Rachel LaneSenior Vice President, Business Development and Operations
Ian McCafferySenior Vice President, Translational Science and Early Clinical Development

Funding History

2024-04
Launch financing (Series A per Crunchbase; classified as Series D by Tracxn)More than $1B

ARCH Venture Partners, Foresite Capital, Foresite Labs

2025-08
Series A$800M

Recent News

2026-07-08partnership
Secretive AI drug hunter Xaira dips toe into dealmaking with hunt for partners

BioSpace reported that Xaira is beginning to reveal more about its capabilities and is looking for partners to help validate its pipeline. The coverage describes the company as having emerged with approximately $1 billion and previously operating largely out of public view.

2026-07-06
Xaira Therapeutics Announces the Appointment of Dr. Ian McCaffery as SVP, Translational Science and Early Clinical Development, and the Promotions of Dr. Ci Chu to Chief Discovery Officer and Dr. Bo Wang to Chief AI Scientist

Xaira appointed Ian McCaffery as senior vice president of translational science and early clinical development, while promoting Ci Chu to chief discovery officer and Bo Wang to chief AI scientist.

2026-03-26
Xaira Therapeutics Announces the Appointment of Rachel Lane, Ph.D., as Senior Vice President, Business Development and Operations

Xaira appointed Rachel Lane, Ph.D., as senior vice president of business development and operations, strengthening the company’s commercial and operational leadership as it advances its AI-driven drug-discovery pipeline.

2026-03-25product
Xaira’s First Virtual Cell Model Is Largest To-Date, Toward Complex Biology

Genetic Engineering & Biotechnology News covered Xaira’s first virtual cell model and its effort to apply large-scale biological data and AI to increasingly complex biology.

2026-03-17product
Xaira Therapeutics Launches X-Cell, Its First Virtual Cell Model, Trained on the Largest-Ever Genome-Wide Perturbation Dataset, X-Atlas/Pisces

Xaira launched X-Cell, its first virtual cell model, trained on the X-Atlas/Pisces genome-wide perturbation dataset. The product is designed to use causal biological data to predict cellular responses to genetic interventions.

2026-02-27funding
Three Bay Area life sciences firms go public after IPO surge

San Francisco Business Journal coverage noted that Xaira raised $800 million in 2025 for its generative-AI drug-discovery platform, placing it among the Bay Area’s prominent life-sciences financings.

2026-01-29
How AI is Driving Drug Discovery: Xaira Therapeutics’ Marc Tessier-Lavigne

Goldman Sachs interviewed Xaira co-founder, chairman, and CEO Marc Tessier-Lavigne about how AI is being used to drive drug discovery and development.

2026-01-16
‘The moat is data’: Marc Tessier-Lavigne on building an AI-native drug company

Onyx Newsroom profiled Xaira’s push toward a more predictive, AI-native drug-discovery model, emphasizing the strategic importance of biological data.

2025-11-12
Reinventing Drug Discovery with AI: Marc Tessier-Lavigne on the Long Run

Timmerman Report discussed Xaira’s long-term AI strategy and its use of computers to design protein drugs from scratch.

2025-10-27
Virtual Cells: Four Paths To A Digital Revolution In Drug Discovery

Citeline examined the emerging virtual-cell field and included Xaira among the companies pursuing computational models to transform drug discovery.

Active Roles

22
South San Francisco, California, United States/Engineering/1d ago
South San Francisco, California, United States/Engineering/5d ago
Seattle, Washington, United States; South San Francisco, California, United States/Engineering/7d ago
South San Francisco, California, United States/Engineering/8d ago
South San Francisco, California, United States/Operations/14d ago
Seattle, Washington, United States/Engineering/15d ago
South San Francisco, California, United States/Engineering/17d ago
South San Francisco, California, United States/Sales/21d ago
South San Francisco, California, United States/Operations/21d ago
South San Francisco, California, United States/Finance/21d ago
South San Francisco, California, United States/Engineering/34d ago
South San Francisco, California, United States/Engineering/43d ago
South San Francisco, California, United States/Engineering/43d ago
South San Francisco, California, United States/Engineering/58d ago
Seattle, Washington, United States/Engineering/58d ago
South San Francisco, California, United States/Data & Analytics/58d ago
South San Francisco, California, United States/Engineering/58d ago
South San Francisco, California, United States/Engineering/58d ago
South San Francisco, California, United States/Engineering/58d ago
South San Francisco, California, United States/Engineering/58d ago

Business Model

Xaira does not publish a detailed pricing model. The evidence supports a product-led biotechnology model: it develops proprietary AI-enabled drug-discovery capabilities and therapeutics, with potential commercial revenue from medicines and partnerships or licensing deals rather than a standalone software subscription.

Products

End-to-end predictive and agentic AI models for drug discovery and developmentBiological data platform spanning molecular-to-human data, functional genomics, and proteomicsComputational biology, molecule-design, and de novo protein-design capabilitiesTherapeutic product development across multiple modalitiesX-Atlas public data/model assets, including Orion Viewer and Pisces

Tech Stack

Machine learning and AI/MLPredictive and agentic AI modelsComputational biology and biological discoveryDe novo protein designFunctional genomics and proteomicsMultidimensional biological-data generation and integration

Competitors

Recursion
Insilico Medicine
Generate Biomedicines
Isomorphic Laboratories
Exscientia
Vilya
Valo

Key Investors

Arch Venture Partners, Foresite Capital, Lux Capital, SV Angel, Sequoia Capital, Menlo Ventures, NEA Partners