Companies

Manas AI

manasai.co

Manas AI uses science-based AI models to discover and develop transformative medicines for cancer and rare diseases.

HQNew York City, New York, United States
Employees1-10
Funding$50.6M
1 active role
Profile 6mo agoJobs checked 14h ago
Healthcare AIFoundation Model ProviderB2B SaaSSeries A$50M-$200M

About

Manas AI is an end-to-end, AI-native biopharmaceutical company developing medicines for cancer and rare diseases. It is aimed at the biopharmaceutical drug-development ecosystem and differentiates itself through neuro-symbolic, science-based foundation models that combine AI with chemistry, physics, and biology.

Market

Manas AI competes in the AI-enabled drug discovery and AI-native biopharmaceutical market, with a focus on oncology and rare-disease treatments. Its positioning is differentiated by an end-to-end approach that combines neuro-symbolic and science-based models with first-principles chemistry, physics, biology, generative computational chemistry, customized chemical libraries, and AI-driven candidate filters, rather than offering only a single computational chemistry or discovery tool.

Target Customers

Manas AI primarily targets biopharmaceutical and pharmaceutical drug-discovery organizations, particularly R&D teams working on oncology and rare diseases. Likely buyers include drug-discovery, medicinal-chemistry, computational-biology, and pharmaceutical R&D leaders seeking to shorten development timelines and improve candidate selection.

At a Glance

Problem

Traditional drug development is a critical bottleneck to human health: it is slow, expensive, and constrained by the difficulty of searching enormous chemical spaces and predicting which molecules will safely bind and affect biological targets. Manas AI frames the economic opportunity as improving speed, cost-efficiency, molecular precision, and ultimately the likelihood that a candidate succeeds in the clinic. Its central use case is accelerating the discovery of medicines for serious, underserved diseases, initially aggressive cancers such as triple-negative breast cancer, prostate cancer, and lymphoma, with ambitions extending to rare and autoimmune diseases.

The company’s launch materials describe a process that can take a decade being compressed to a few years, with AI helping researchers explore chemical possibilities and molecular interactions at dramatically greater speed. The pain is therefore not merely laboratory productivity; it is the delay and financial risk between identifying a therapeutic target and getting an effective treatment to patients.

Product / Service

Manas AI is building a full-stack, AI-native biopharmaceutical platform rather than presenting itself simply as a point software tool. It combines neuro-symbolic, science-based foundation models with first-principles chemistry, physics, and biology, and applies them across target identification, molecular discovery, validation, and clinical development. The platform is intended to support multiple therapeutic modalities, including small molecules, antibodies, and siRNA, while keeping human scientific expertise in the loop to select viable and safe leads.

Operationally, Manas generates bespoke chemical libraries and uses AI filters to identify promising candidates, then applies large-scale molecular docking and computational chemistry to predict how compounds interact with target proteins. Its Microsoft Azure collaboration was designed to run docking at speeds described as 100 times faster than traditional systems, while Project Cosmos aims to map the fundamental rules of drug binding. More recently, the company announced a multi-year Schrödinger agreement combining Schrödinger’s physics-based modeling with Manas’s machine-learning models, with the intended benefit of shorter discovery timelines and better predictive accuracy.

Market

Manas AI competes in AI-driven drug discovery and the broader AI-native biopharmaceutical market, particularly the emerging category of end-to-end computational drug development for oncology and rare disease. Comparable companies named in market coverage include Owkin, BenevolentAI, Insilico Medicine, and Valo Health, which compete for partnerships and contracts with pharmaceutical companies. Manas’s differentiation is its full-stack therapeutics focus, science-based and neuro-symbolic modeling, emphasis on oncology, and integration of AI with physics-based molecular simulation rather than relying on generic machine learning alone.

The company launched publicly in January 2025 with $24.6 million in seed funding led by General Catalyst and Reid Hoffman, followed by a $26 million seed extension announced in September 2025. It has also established collaborations with Microsoft and Schrödinger and has continued developing its foundational models and therapeutic campaigns. The available evidence shows an early, privately held company focused on platform and pipeline development; it does not report revenue, customers, or a clinical-stage drug, so Manas is best characterized as pre-commercial or pre-revenue on the disclosed record rather than as a company with validated product sales or clinical traction.

Founders & Leadership

Siddhartha MukherjeeFounder
Co-Founder & CEO
Reid HoffmanFounder
Co-Founder
Ujjwal SinghFounder
Co-Founder & CTO
Jonathan BaellChief Scientific Officer
Erez KalirChief Operating Officer

Funding History

2025-01
Seed$24.6M

General Catalyst, Reid Hoffman

2025-09
Seed Extension$26M

The General Partnership, Wisdom Ventures, Blitzscaling Ventures, Westbound Equity Partners, Mosaic Ventures, Unnamed individual investors

Recent News

2026-01-12partnership
Manas AI Secures Strategic Advantage through Unique Deep Integration with Schrödinger’s Physics + AI Discovery Platform

Manas AI announced a strategic agreement with Schrödinger granting significant access to its physics-based computational molecular-discovery platform. The arrangement includes ultra-large-scale platform access, priority scientific and technical support, and integration of Schrödinger’s physics-based modeling with Manas AI’s machine-learning models.

2025-09-24funding
Manas AI: $26 Million Seed Extension Closed For AI-Based Drug Discovery Platform

Pulse 2.0 reported that Manas AI closed a $26 million seed-extension round and appointed Ujjwal Singh as co-founder and chief technology officer. The funding is intended to accelerate the company’s drug-discovery foundational models and therapeutic campaigns.

2025-09-23funding
Manas AI Announces $26M Seed Extension and the Appointment of Ujjwal Singh as Co-Founder and Chief Technology Officer

Manas AI announced the closing of a $26 million seed extension and the appointment of Ujjwal Singh as co-founder and CTO. The company said it will use the funds to develop its drug-discovery foundational models, advance therapeutic campaigns, and expand its interdisciplinary team.

Active Roles

1
Singapore/Product/193d ago

Business Model

Manas AI has an asset-centric biopharmaceutical model: it uses proprietary AI and scientific models to discover and develop therapeutic candidates, intending to bring successful medicines to market. Public evidence does not disclose subscription pricing or current revenue; monetization is therefore best understood as future therapeutic commercialization and potential biopharma partnerships or licensing rather than a documented software-fee model.

Products

Full-stack, AI-native drug discovery and development platformNeuro-symbolic, science-based foundational models for discovering medicinesGenerative computational chemistry and biology workflowsCustomized chemical libraries and AI filters for identifying therapeutic candidates

Customers

Microsoft — publicly identified strategic/cloud-computing partner; not explicitly disclosed as a customerSchrödinger, Inc. — publicly identified strategic platform partner; not explicitly disclosed as a customer

Tech Stack

Artificial intelligenceNeuro-symbolic AIScience-based foundational/frontier modelsGenerative computational chemistryComputational biologyFirst-principles chemistry, physics, and biologyAI-based chemical-library customization and therapeutic-candidate filters

Competitors

Schrödinger
Recursion Pharmaceuticals
Valo Health

Key Investors

General Catalyst, Greylock, Mosaic Ventures, Reid Hoffman